Multicomponent Synthesis of Functionalized Tetrahydroacridinones: Insights into a Mechanistic Route

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• 作者：Tsai-Wen Chung ; Bharat D. Narhe ; Chun-Cheng Lin ; Chung-Ming Sun
• 刊名：Organic Letters
• 出版年：2015
• 出版时间：November 6, 2015
• 年：2015
• 卷：17
• 期：21
• 页码：5368-5371
• 全文大小：350K
• ISSN：1523-7052

文摘

A mechanistic study of three-component reactions of various aromatic amines with a number of aldehydes and 1,3-diones was achieved. The unprecedented reaction involved a nucleophilic attack of an aromatic amine on the in situ generated Michael adduct intermediate followed by six-electron ring cyclizations. It is contrary to the common belief that advocates involvement of coupling reactions between a Knoevenagel adduct and an aromatic amine to deliver substituted tetrahydroacridinones.