A rapid scan on a quadrupole ion trap mass spectrometercan improve the signal intensity by over 200 times whenscanning at 12 times the normal scan rate. This intensityincrease is due to a 5.5-fold increase in mass peak heightdue to a reduction in the mass peak width over time anda 40-fold increase in signal from the increased numberof ions that can be trapped without the deleterious effectsof space charge. Detection limits can be further improvedby signal averaging more scans in the same period that isrequired for the normal scan, and the greatest advantageoccurs when scanning over the full mass range. The rapidscan impacts the mass accuracy and the resolution isreduced by 6 times. The molecular weight determinationof 40 fmol/
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L apomyoglobin was determined in 3 s usinga rapid scan, but this was not possible when using thenormal scan rate. Quantitation results showed that therelative standard deviations for the total ion current peakareas of 500 fmol of angiotensin I were improved by afactor of 2.6 when the rapid scan was used.