Ugi/Himbert Arene/Allene Diels鈥揂lder Cycloaddition to Synthesize Strained Polycyclic Skeleton

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• 作者：Guangsheng Cheng ; Xiang He ; Lumin Tian ; Jiawen Chen ; Chunju Li ; Xueshun Jia ; Jian Li
• 刊名：Journal of Organic Chemistry
• 出版年：2015
• 出版时间：November 6, 2015
• 年：2015
• 卷：80
• 期：21
• 页码：11100-11107
• 全文大小：411K
• ISSN：1520-6904

文摘

The present work disclosed an efficient multicomponent reaction of isocyanide, allenic acid, aldehyde (ketone), and aniline. This protocol undergoes Ugi reaction followed by an intramolecular arene/allene Diels鈥揂lder sequence, thus providing a rapid access to synthesize strained polycyclic skeletons.