Dysregulation of Retinoid Transporters Expression in Body Fluids of Schizophrenia Patients

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• 作者：Chunling Wan ; Yifeng Yang ; Huafang Li ; Yujuan La ; Hui Zhu ; Lei Jiang ; Yongshuo Chen ; Guoyin Feng ; Lin He
• 刊名：Journal of Proteome Research
• 出版年：2006
• 出版时间：November 2006
• 年：2006
• 卷：5
• 期：11
• 页码：3213 - 3216
• 全文大小：137K
• 年卷期：v.5,no.11(November 2006)
• ISSN：1535-3907

文摘

This study aims to find the biomarkers or associated proteins in body fluids of schizophrenia patientsso that we can further understand the etiology of schizophrenia. We applied proteomic technologiescombining two-dimensional electrophoresis with Coomassie blue staining and mass spectrometry andidentifyed a procedure for the clinical screening of disease-influenced body fluid proteins in two setsof samples, plasma from 19 schizophrenia patients and cerebrospinal fluid (CSF) from 35 drug-treatedschizophrenic patients and 36 healthy controls. The expression of transthyretin (TTR) tetramer increasedsignificantly in plasma of schizophrenic patients after a valid 2 months in-hospital antipsychotictreatment. Conversely, the expression of the TTR tetramer and apolipoprotein E (ApoE) was down-regulated by up to 1.68 and 3.62 times, respectively, in the CSF of schizophrenia patients compared tothat of normal controls, which has not been reported previously. Considering that the TTR tetramerand ApoE are both retinoid transporters, retinoid dysfunction might be involved in the pathology ofschizophrenia.