Synthesis of 2H-Indazoles by the [3 + 2] Dipolar Cycloaddition of Sydnones with Arynes

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• 作者：Yuesi Fang ; Chunrui Wu ; Richard C. Larock ; Feng Shi
• 刊名：Journal of Organic Chemistry
• 出版年：2011
• 出版时间：November 4, 2011
• 年：2011
• 卷：76
• 期：21
• 页码：8840-8851
• 全文大小：521K
• 年卷期：v.76,no.21(November 4, 2011)
• ISSN：1520-6904

文摘

A rapid and efficient synthesis of 2H-indazoles has been developed using a [3 + 2] dipolar cycloaddition of sydnones and arynes. A series of 2H-indazoles have been prepared in good to excellent yields using this protocol, and subsequent Pd-catalyzed coupling reactions can be applied to the halogenated products to generate a structurally diverse library of indazoles.