Iron Catalyzed Highly Enantioselective Epoxidation of Cyclic Aliphatic Enones with Aqueous H2O2
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- 作者：Olaf Cussó ; Marco Cianfanelli ; Xavi Ribas ; Robertus J. M. Klein Gebbink ; Miquel Costas
- 刊名：Journal of the American Chemical Society
- 出版年：2016
- 出版时间：March 2, 2016
- 年：2016
- 卷：138
- 期：8
- 页码：2732-2738
- 全文大小：525K
- ISSN：1520-5126
文摘
An iron complex with a C1-symmetric tetradentate N-based ligand catalyzes the asymmetric epoxidation of cyclic enones and cyclohexene ketones with aqueous hydrogen peroxide, providing the corresponding epoxides in good to excellent yields and enantioselectivities (up to 99% yield, and 95% ee), under mild conditions and in short reaction times. Evidence is provided that reactions involve an electrophilic oxidant, and this element is employed in performing site selective epoxidation of enones containing two alkene sites.