Bioactive Sulfur-Containing Sulochrin Dimers and Other Metabolites from an Alternaria sp. Isolate from a Hawaiian Soil Sample

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• 作者：Shengxin Cai ; Jarrod B. King ; Lin Du ; Douglas R. Powell ; Robert H. Cichewicz
• 刊名：Journal of Natural Products
• 出版年：2014
• 出版时间：October 24, 2014
• 年：2014
• 卷：77
• 期：10
• 页码：2280-2287
• 全文大小：367K
• ISSN：1520-6025

文摘

Polluxochrin (1) and dioschrin (2), two new dimers of sulochrin linked by thioether bonds, were purified from an Alternaria sp. isolate obtained from a Hawaiian soil sample. The structures of the two metabolites were established by NMR, mass spectrometry data, and X-ray analysis. Metabolite 1 was determined to be susceptible to intramolecular cyclization under aqueous conditions, resulting in the generation of 2 as well as another dimeric compound, castochrin (3). An additional nine new metabolites were also obtained, including four new pyrenochaetic acid derivatives (8鈥?b>11), one new asterric acid analogue (13), and four new secalonic acid analogues (14鈥?b>17). Bioassay analysis of these compounds revealed 1鈥?b>3 displayed antimicrobial and weak cytotoxic activities.