In Vitro Activity of the Essential Oil of Cinnamomum zeylanicum and Eugenol in Peroxynitrite-Induced Oxidative Processes
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- 作者：Silvio Chericoni ; José ; M. Prieto ; Patrizia Iacopini ; Pierluigi Cioni ; and Ivano Morelli
- 刊名：Journal of Agricultural and Food Chemistry
- 出版年：2005
- 出版时间：June 15, 2005
- 年：2005
- 卷：53
- 期：12
- 页码：4762 - 4765
- 全文大小：40K
- 年卷期：v.53,no.12(June 15, 2005)
- ISSN：1520-5118
文摘
The essential oil obtained from the bark of Cinnamomum zeylanicum Blume (Lauraceae) and threeof its main components, eugenol, (E)-cinnamaldehyde, and linalool (representing 82.5% of the totalcomposition), were tested in two in vitro models of peroxynitrite-induced nitration and lipid peroxidation.The essential oil and eugenol showed very powerful activities, decreasing 3-nitrotyrosine formationwith IC50 values of 18.4 
g/mL and 46.7 M, respectively (reference compound, ascorbic acid, 71.3g/mL and 405.0 M) and also inhibiting the peroxynitrite-induced lipid peroxidation showing an IC50of 2.0 g/mL and 13.1 M, respectively, against 59.0 g/mL (235.5 M) of the reference compoundTrolox. On the contrary, (E)-cinnamaldehyde and linalool were completely inactive.Keywords: Peroxynitrite; lipid peroxidation; 3-nitrotyrosine; Cinnamomum zeylanicum; essential oil;eugenol
g/mL and 46.7 M, respectively (reference compound, ascorbic acid, 71.3g/mL and 405.0 M) and also inhibiting the peroxynitrite-induced lipid peroxidation showing an IC50of 2.0 g/mL and 13.1 M, respectively, against 59.0 g/mL (235.5 M) of the reference compoundTrolox. On the contrary, (E)-cinnamaldehyde and linalool were completely inactive.Keywords: Peroxynitrite; lipid peroxidation; 3-nitrotyrosine; Cinnamomum zeylanicum; essential oil;eugenol