Action at a Distance: Functional Drug Delivery Using Electromagnetic-Field-Responsive Polypyrrole Nanowires

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• 作者：Wen Gao ; Jianming Li ; John Cirillo ; Richard Borgens ; Youngnam Cho
• 刊名：Langmuir
• 出版年：2014
• 出版时间：July 8, 2014
• 年：2014
• 卷：30
• 期：26
• 页码：7778-7788
• 全文大小：742K
• ISSN：1520-5827

文摘

In this work, we introduce a free-standing, vertically aligned conductive polypyrrole (Ppy) architecture that can serve as a high-capacity drug reservoir. This novel geometric organization of Ppy provides a new platform for improving the drug-loading efficiency. Most importantly, we present the first formal evidence that an impregnated drug (dexamethasone, DEX) can be released on demand by a focal, pulsatile electromagnetic field (EMF). This remotely controlled, on鈥搊ff switchable polymer system provides a framework for implantable constructs that can be placed in critical areas of the body without any physical contact (such as percutaneous electrodes) with the Ppy, contributing to a low 鈥渇oreign body鈥?footprint. We demonstrate this possibility by using a BV-2 microglia culture model in which reactive oxygen species (ROS) and inducible nitric oxide synthase (iNOS) expression was attenuated in response to DEX released from EMF-stimulated Ppy.