Microwave-Enhanced Solid-Phase Synthesis of N,N鈥?/i>-Linked Aliphatic Oligoureas and Related Hybrids
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- 作者：C茅line Douat-Casassus ; Karolina Pulka ; Paul Claudon ; Gilles Guichard
- 刊名：Organic Letters
- 出版年：2012
- 出版时间：June 15, 2012
- 年：2012
- 卷：14
- 期：12
- 页码：3130-3133
- 全文大小：266K
- 年卷期：v.14,no.12(June 15, 2012)
- ISSN：1523-7052
文摘
A practical and efficient microwave-assisted solid-phase method for the synthesis of N,N鈥?/i>-linked oligoureas and related amide/urea hybrid oligomers, featuring the use of succinimidyl (2-azido-2-substituted ethyl) carbamate monomers, is reported. The rate enhancement of urea formation under microwave irradiation combined with the mild conditions of the phosphine-based azide reduction makes this approach very effective for routine synthesis of oligoureas and possibly for library production.