Total Synthesis of Baccatin III and Taxol
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- 作者：Samuel J. Danishefsky ; John J. Masters ; Wendy B. Young ; J. T. Link ; Lawrence B. Snyder ; Thomas V. Magee ; David K. Jung ; Richard C. A. Isaacs ; William G. Bornmann ; Cheryl A. Alaimo ; Craig A. Coburn ; an
- 刊名：Journal of the American Chemical Society
- 出版年：1996
- 出版时间：March 27, 1996
- 年：1996
- 卷：118
- 期：12
- 页码：2843 - 2859
- 全文大小：820K
- 年卷期：v.118,no.12(March 27, 1996)
- ISSN：1520-5126
文摘
An intramolecular Heck reaction (90 
91)serves as the key step in the total synthesis of thetitledcompounds. The synthetic route is based on utilizing theWieland-Miescher ketone (5) as a matrix to providetheC and D rings of the targets and to provide functionality implementsfor joining this sector to an A ring precursor(6). Catalytically induced enantiotopic control andearly emplacement of the oxetane are other features of theroute.
91)serves as the key step in the total synthesis of thetitledcompounds. The synthetic route is based on utilizing theWieland-Miescher ketone (5) as a matrix to providetheC and D rings of the targets and to provide functionality implementsfor joining this sector to an A ring precursor(6). Catalytically induced enantiotopic control andearly emplacement of the oxetane are other features of theroute.