Biotransformation of Bioactive Isocaryolanes by Botrytis cinerea

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• 作者：Jociani Ascari ; Maria Ame虂lia Diamantino Boaventura ; Jacqueline Aparecida Takahashi ; Rosa Dura虂n-Patro虂n ; Rosario Herna虂ndez-Gala虂n ; Antonio J. Maci虂as-Sa虂nchez ; Isidro G. Collado
• 刊名：Journal of Natural Products
• 出版年：2011
• 出版时间：August 26, 2011
• 年：2011
• 卷：74
• 期：8
• 页码：1707-1712
• 全文大小：798K
• 年卷期：v.74,no.8(August 26, 2011)
• ISSN：1520-6025

文摘

The metabolism of the fungistatic agent (8R,9R)-8-methoxyisocaryolan-9-ol (4) by the fungus Botrytis cinerea has been investigated. Biotransformation of compound 4 yielded compounds 5 and 6鈥?b>9. No dihydrobotrydial is observed after 4 days of incubation of compound 4. Separate biotransformation of (8R,9R)-isocaryolane-8,9-diol (5) yielded compounds 7鈥?b>11. The evaluation of the fungistatic activity against B. cinerea of compounds 4, 5, and 6 is reported. (4R,8R,9R)-8-Methoxyisocaryolane-9,15-diol (6), a major metabolite of (8R,9R)-8-methoxyisocaryolan-9-ol (4), shows a much reduced biological activity when compared with the parent compound. Isocaryolane derivatives 6鈥?b>11 are described for the first time.