Scale-down of Heterogeneous Catalytic Reduction Using a Bubble Column: Controlled Mass Transfer down to 3 cm3 Working Volume

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• 作者：John H. Atherton ; Ahmed Elmekawy ; Alan Hall ; Howard Williams
• 刊名：Organic Process Research & Development
• 出版年：2015
• 出版时间：September 18, 2015
• 年：2015
• 卷：19
• 期：9
• 页码：1159-1163
• 全文大小：244K
• ISSN：1520-586X

文摘

Best practice for scale-down of gas鈥搇iquid reactions requires control of the volumetric mass transfer coefficient, k_La. It is demonstrated that the use of small bubble columns can provide well-controlled k_La and catalyst dispersion down to a scale of 3 cm³. This scale is several times less than has been previously demonstrated for heterogeneously catalysed reduction using gaseous hydrogen and is more easily reproduced than small scale stirred vessels. Measurements have been made at a fixed total gas flow, with the effective mass transfer rate being adjustable by dilution of the hydrogen flow with either helium or nitrogen.