Synthesis of a Platform To Access Bistramides and Their Analogues

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• 作者：Malgorzata Commandeur ; Claude Commandeur ; Janine Cossy
• 刊名：Organic Letters
• 出版年：2011
• 出版时间：November 18, 2011
• 年：2011
• 卷：13
• 期：22
• 页码：6018-6021
• 全文大小：797K
• 年卷期：v.13,no.22(November 18, 2011)
• ISSN：1523-7052

文摘

The platform C14鈥揅40, which can be used to prepare bistramide C and 39-oxobistramide K, was synthesized in 19 steps with an overall yield of 6.2%. Furthermore, the chemoselective reduction of the ketone at C-39 was performed giving an easy access to bistramides A, B, D, K, and L. Finally, the versatility of the synthesis of the C14鈥揅40 fragment can allow the preparation of a large variety of stereoisomers to produce bistramide analogues.