Copper-Catalyzed C鈥揌 Azidation of Anilines under Mild Conditions

详细信息    查看全文

• 作者：Conghui Tang ; Ning Jiao
• 刊名：The Journal of the American Chemical Society
• 出版年：2012
• 出版时间：November 21, 2012
• 年：2012
• 卷：134
• 期：46
• 页码：18924-18927
• 全文大小：296K
• 年卷期：v.134,no.46(November 21, 2012)
• ISSN：1520-5126

文摘

A novel and efficient copper-catalyzed azidation reaction of anilines via C鈥揌 activation has been developed. This method, in which the primary amine acts as a directing group by coordinating to the metal center, provides ortho azidation products regioselectively under mild conditions. This effective route for the synthesis of aryl azides is of great significance in view of the versatile reactivity of the azide products.