Acceleration of the Morita−Baylis−Hillman Reaction by a Simple Mixed Catalyst System
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- 作者：Alejandro Bugarin ; Brian T. Connell
- 刊名：Journal of Organic Chemistry
- 出版年：2009
- 出版时间：June 19, 2009
- 年：2009
- 卷：74
- 期：12
- 页码：4638-4641
- 全文大小：173K
- 年卷期：v.74,no.12(June 19, 2009)
- ISSN：1520-6904
文摘
By using a catalytic amount of 4-dimethylaminopyridine (DMAP) as a nucleophile in the presence of an equal amount of tetramethylethylenediamine (TMEDA) and MgI2, Morita−Baylis−Hillman adducts can be obtained in good to excellent yields from various aromatic and aliphatic aldehydes and cyclic enones/enoates at room temperature after convenient reaction times.