Synthesis of Substituted Acetylenic Epoxides Followed by Indium-Catalyzed Rearrangement to 2,3,5-Trisubstituted Furans

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• 作者：Jun Yong Kang ; Brian T. Connell
• 刊名：Journal of Organic Chemistry
• 出版年：2011
• 出版时间：April 1, 2011
• 年：2011
• 卷：76
• 期：7
• 页码：2379-2383
• 全文大小：737K
• 年卷期：v.76,no.7(April 1, 2011)
• ISSN：1520-6904

文摘

Syntheses of various aromatic and aliphatic 2,3,5-trisubstituted furans from acetylenic epoxides are described. These epoxides are directly prepared by nucleophilic ring closure of propargylic alkoxides generated by lithium acetylide addition to 伪-haloketones.