Tetrahydroquinolines via Stereospecific [3 + 3]-Annulation of Donor–Acceptor Cyclopropanes with Nitrosoarenes

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• 作者：Saikat Das ; Shyamal Chakrabarty ; Constantin G. Daniliuc ; Armido Studer
• 刊名：Organic Letters
• 出版年：2016
• 出版时间：June 3, 2016
• 年：2016
• 卷：18
• 期：11
• 页码：2784-2787
• 全文大小：362K
• 年卷期：0
• ISSN：1523-7052

文摘

A stereospecific [3 + 3]-annulation of donor–acceptor cyclopropanes with nitrosoarenes under the influence of MgBr₂ as a stoichiometric Lewis acid and reagent offers a novel approach to various structurally diverse C-8-brominated tetrahydroquinolines. In these cascades C–C, C–N, and C–Br bonds are formed. The reactions are easy to conduct and proceed under mild conditions, and the products can readily be further functionalized, rendering the method highly valuable.