文摘
The sesquiterpene nanaimoal was synthesized in 21% overallyield and in a biomimetic manner. As a key step, the acid-catalyzed cyclization of farnesal under zeolite NaY confinement conditions was used. The intrazeolite cyclization offarnesal affords as major product a double-bond isomer ofnanaimoal, via a novel diastereoselective tandem 1,5-dienecyclization/Prins-type reaction.