On-Demand Removal of Bacterial Biofilms via Shape Memory Activation

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• 作者：Huan Gu ; Sang Won Lee ; Shelby Lois Buffington ; James H. Henderson ; Dacheng Ren
• 刊名：ACS Applied Materials & Interfaces
• 出版年：2016
• 出版时间：August 24, 2016
• 年：2016
• 卷：8
• 期：33
• 页码：21140-21144
• 全文大小：306K
• 年卷期：0
• ISSN：1944-8252

文摘

Bacterial biofilms are a major cause of chronic infections and biofouling; however, effective removal of established biofilms remains challenging. Here we report a new strategy for biofilm control using biocompatible shape memory polymers with defined surface topography. These surfaces can both prevent bacterial adhesion and remove established biofilms upon rapid shape change with moderate increase of temperature, thereby offering more prolonged antifouling properties. We demonstrate that this strategy can achieve a total reduction of Pseudomonas aeruginosa biofilms by 99.9% compared to the static flat control. It was also found effective against biofilms of Staphylococcus aureus and an uropathogenic strain of Escherichia coli.