Synthesis and Biological Action of Novel 4-Position-Modified Derivatives of D-myo-Inositol 1,4,5-Trisphosphate

详细信息    查看全文

• 作者：Davide Bello ; Tashfeen Aslam ; Geert Bultynck ; Alexandra M. Z. Slawin ; H. Llewelyn Roderick ; Martin D. Bootman ; Stuart J. Conway
• 刊名：Journal of Organic Chemistry
• 出版年：2007
• 出版时间：July 20, 2007
• 年：2007
• 卷：72
• 期：15
• 页码：5647 - 5659
• 全文大小：520K
• 年卷期：v.72,no.15(July 20, 2007)
• ISSN：1520-6904

文摘

jo070611an00001>

journals/joceah/72/i15/figures/jo070611an00001.gif" ALIGN="left" HSPACE=5>

The design of a range of 4-position-modified D-myo-inositol 1,4,5-trisphosphate derivatives is described.The enantioselective synthesis of these compounds is reported, along with initial biological analysis,which indicates that these compounds do not act as D-myo-inositol 1,4,5-trisphosphate receptor agonistsor antagonists.