Synthetic Studies on the MARDi Cascade: Stereoselective Synthesis of Heterocyclic Seven-Membered Rings

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• 作者：Yoann Coquerel ; David Bensa ; Alain Doutheau ; Jean Rodriguez
• 刊名：Organic Letters
• 出版年：2006
• 出版时间：October 12, 2006
• 年：2006
• 卷：8
• 期：21
• 页码：4819 - 4822
• 全文大小：62K
• 年卷期：v.8,no.21(October 12, 2006)
• ISSN：1523-7052

文摘

A versatile stereoselective synthesis of substituted and functionalized heterocyclic seven-membered rings is described. The approach involvesa formal two-carbon ring expansion of heterocyclic cyclopentanones through a base-induced anionic domino three-component transformationnamed the MARDi cascade leading either to oxa-, aza-, or thiacycloheptanes bearing up to five contiguous stereogenic centers.