Suppression of EGFR Autophosphorylation by FKBP12

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• 作者：Sebastian Mathea ; Sen Li ; Angelika Schierhorn ; G眉nther Jahreis ; Cordelia Schiene-Fischer
• 刊名：Biochemistry
• 出版年：2011
• 出版时间：December 20, 2011
• 年：2011
• 卷：50
• 期：50
• 页码：10844-10850
• 全文大小：362K
• 年卷期：v.50,no.50(December 20, 2011)
• ISSN：1520-4995

文摘

FK506 binding proteins (FKBPs) represent a subfamily of peptidyl prolyl cis/trans isomerases that can control receptor-mediated intracellular signaling. The prototypic PPIase FKBP12 functionally interacts with EGFR. FKBP12 was shown to inhibit EGF-induced EGFR autophosphorylation with all internal phosphorylation sites equally affected. The inhibition of EGFR catalytic activity is conducted by targeting the EGFR kinase domain. The change of intracellular FKBP12 levels resulted in a change of EGFR autophosphorylation level. Collectively, our results demonstrate that FKBP12 forms an endogenous inhibitor of EGFR phosphorylation directly involved in the control of cellular EGFR activity.