Synthesis of Redox Active Ferrocene-Modified Phospholipids by Transphosphatidylation Reaction and Chronoamperometry Study of the Corresponding Redox Sensitive Liposome

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• 作者：Debby Correia-Ledo ; Alexandre A. Arnold ; Janine Mauzeroll
• 刊名：Journal of the American Chemical Society
• 出版年：2010
• 出版时间：November 3, 2010
• 年：2010
• 卷：132
• 期：43
• 页码：15120-15123
• 全文大小：159K
• 年卷期：v.132,no.43(November 3, 2010)
• ISSN：1520-5126

文摘

The design of stable redox active liposomes where the organometallic electroactive pendent was covalently bound to the phospholipid headgroup through a phospholipase D (PLD)-catalyzed transphosphatidylation reaction between a choline-bearing phospholipid and a primary alcohol containing a ferrocene derivative is reported. The functionalization of a liposome surface with this organometallic redox phospholipid allowed the study of membrane-bound electrochemical reactions, which are important in the design of redox-sensitive liposome delivery systems.