Design, Synthesis, and Photochemical Validation of Peptide Linchpins Containing the S,S-Tetrazine Phototrigger

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• 作者：Mohannad Abdo ; Stephen P. Brown ; Joel R. Courter ; Matthew J. Tucker ; Robin M. Hochstrasser ; Amos B. Smith ; III
• 刊名：Organic Letters
• 出版年：2012
• 出版时间：July 6, 2012
• 年：2012
• 卷：14
• 期：13
• 页码：3518-3521
• 全文大小：280K
• 年卷期：v.14,no.13(July 6, 2012)
• ISSN：1523-7052

文摘

The design, solid-phase synthesis, and photochemical validation of diverse peptide linchpins, containing the S,S-tetrazine phototrigger, have been achieved. Steady state irradiation or femtosecond laser pulses confirm their rapid photofragmentation. Attachment of peptides to the C- and N-termini will provide access to diverse constrained peptide constructs that hold the promise of providing information about early peptide/protein conformational dynamics upon photochemical release.