Analysis of Phospholipid Bilayers on Gold Nanorods by Plasmon Resonance Sensing and Surface-Enhanced Raman Scattering

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• 作者：James R. Matthews ; Courtney M. Payne ; Jason H. Hafner
• 刊名：Langmuir
• 出版年：2015
• 出版时间：September 15, 2015
• 年：2015
• 卷：31
• 期：36
• 页码：9893-9900
• 全文大小：450K
• ISSN：1520-5827

文摘

Surface-enhanced Raman scattering (SERS) and localized surface plasmon resonance sensing (LSPR) have been applied for a detailed analysis of lipid bilayers at the surface of gold nanorods. The spatial dependence of surface enhancement and the optical effects of the lipid phase transition confirm the presence of a bilayer membrane structure. Deuterated lipids exchanged rapidly between the nanorod surface and lipid vesicles in solution, suggesting a loosely bound, natural membrane structure. However, at a low solution concentration of lipid vesicles, the lipids on the gold nanorod surface convert to a nonbilayer structure, which could impact biological applications of these nanomaterials.