Antibiotic Indole Sesquiterpene Alkaloid from Greenwayodendron suaveolens with a New Natural Product Framework

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• 作者：Russell B. Williams ; Jin-Feng Hu ; Krista M. Olson ; Vanessa L. Norman ; Matt G. Goering ; Mark O’ ; Neil-Johnson ; Gary R. Eldridge ; Courtney M. Starks
• 刊名：Journal of Natural Products
• 出版年：2010
• 出版时间：May 28, 2010
• 年：2010
• 卷：73
• 期：5
• 页码：1008-1011
• 全文大小：115K
• 年卷期：v.73,no.5(May 28, 2010)
• ISSN：1520-6025

文摘

High-throughput natural products chemistry methods have led to the isolation of three new (1−3) and two known indole sesquiterpene alkaloids (4, 5) from Greenwayodendron suaveolens. Their structures were determined using CapNMR and MS. Pentacyclindole (1) was determined to possess a new natural product framework. Pentacyclindole (1) and polyalthenol (4) showed activity against clinical isolates of Staphylococcus aureus with polyalthenol (4) demonstrating a MIC₉₀ of 4 μg/mL.