Acetylated Dammarane-Type Bisdesmosides from Combretum inflatum

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• 作者：Russell B. Williams ; Vanessa L. Norman ; Matt G. Goering ; Mark O鈥橬eil-Johnson ; Gary R. Eldridge ; Courtney M. Starks
• 刊名：Journal of Natural Products
• 出版年：2013
• 出版时间：September 27, 2013
• 年：2013
• 卷：76
• 期：9
• 页码：1592-1597
• 全文大小：246K
• 年卷期：v.76,no.9(September 27, 2013)
• ISSN：1520-6025

文摘

The first study of the chemical constituents of Combretum inflatum has resulted in the isolation of seven new acetylated dammarane-type bisdesmosides (1鈥?b>7). Their structures were determined from microgram quantities on hand using Bruker BioSpin TCI 1.7 mm MicroCryoProbe technology, ESIMS, and comparison to data found in the literature. Compounds 1鈥?b>7 were screened for inhibition of an Escherichia coli strain UTI89 biofilm, MRSA inhibition, and cytotoxicity in NCI-H460 human lung cancer cells. Compounds 3鈥?b>7 reduced the growth of MRSA at 16 渭g/mL by 71鈥?5%, and compound 7 had an IC₅₀ value of 3.9 渭M in NCI-H460.