Cytotoxic and Antibacterial Beilschmiedic Acids from a Gabonese Species of Beilschmiedia
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- 作者：Russell B. Williams ; Steven M. Martin ; Jin-Feng Hu ; Vanessa L. Norman ; Matt G. Goering ; Sandra Loss ; Mark O鈥橬eil-Johnson ; Gary R. Eldridge ; Courtney M. Starks
- 刊名：Journal of Natural Products
- 出版年：2012
- 出版时间：July 27, 2012
- 年：2012
- 卷：75
- 期：7
- 页码：1319-1325
- 全文大小：267K
- 年卷期：v.75,no.7(July 27, 2012)
- ISSN：1520-6025
文摘
High-throughput natural products chemistry methods have facilitated the isolation of eight new (1鈥?b>8) and two known (9 and 10) beilschmiedic acid derivatives from the leaves of a Gabonese species of Beilschmiedia. Compounds 3鈥?b>10 were isolated in microgram quantities, and the NMR data for structure elucidation and dereplication were acquired utilizing a Bruker BioSpin TCI 1.7 mm MicroCryoProbe. All of the compounds were screened for cytotoxic and antibacterial activity against NCI-H460 human lung cancer cells and a clinical isolate of methicillin-resistant Staphylococcus aureus, respectively. This is the first report of cytotoxic activity for the endiandric/beilschmiedic acid class of compounds.