Digging Deep for New Compounds from the Compass Plant, Silphium laciniatum
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- 作者：Russell B. Williams ; Vanessa L. Norman ; Mark O鈥橬eil-Johnson ; Scott Woodbury ; Gary R. Eldridge ; Courtney M. Starks
- 刊名：Journal of Natural Products
- 出版年：2015
- 出版时间：August 28, 2015
- 年：2015
- 卷：78
- 期：8
- 页码：2074-2086
- 全文大小：543K
- ISSN：1520-6025
文摘
The compass plant, Silphium laciniatum, is an iconic perennial plant of the North American tallgrass prairie. The plants of the tallgrass prairie historically have been subjected to a number of biological and environmental stresses. Among the adaptations developed by S. laciniatum is a large deep taproot. An investigation of the secondary metabolites found in the root of a S. laciniatum specimen has led to the identification of 15 new terpenoids (3鈥?b>8, 10鈥?b>17, and 22), which were screened for cytotoxic activity in the NCI-H460 human large-cell lung carcinoma cell line.