A Polysaccharide from a Tea (Infusion) of Maytenus ilicifolia Leaves with Anti-ulcer Protective Effects
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- 作者：Thales R. Cipriani ; Caroline G. Mellinger ; Lauro M. de Souza ; Cristiane H. Baggio ; Cristina S. Freitas ; Maria C. A. Marques ; Philip A. J. Gorin ; Guilherme L. Sassaki ; Marcello Iacomini
- 刊名：Journal of Natural Products
- 出版年：2006
- 出版时间：July 2006
- 年：2006
- 卷：69
- 期：7
- 页码：1018 - 1021
- 全文大小：84K
- 年卷期：v.69,no.7(July 2006)
- ISSN：1520-6025
文摘
Maytenus ilicifolia is a medicinal plant used as a tea (infusion) for treatment of stomach ulcers. This tea furnished apolysaccharide after several purification steps, consisting of a freezing-thawing process, Fehling precipitation,ultrafiltration, and dialysis. It consisted of arabinose, galactose, galacturonic acid, 4-O-methylglucuronic acid, rhamnose,and glucose in a 42:41:6:5:4:2 molar ratio. Methylation analysis, controlled Smith degradation, and NMR spectroscopyindicated that it was a type II arabinogalactan containing a (1
3)-linked 
hars/beta2.gif" BORDER=0 ALIGN="middle">-D-Galp main chain, substituted at O-6 by(16)-linked hars/beta2.gif" BORDER=0 ALIGN="middle">-D-Galp chains, which were mainly substituted at O-3 by (15)- and (13)-linked hars/alpha.gif" BORDER=0>-L-Araf chains, andnonreducing end-units of hars/alpha.gif" BORDER=0>-L-Araf and 4-O-Me-GlcpA. This polysaccharide significantly inhibited ethanol-induced gastriclesions in rats with an ED50 of 9.3 mg/kg, suggesting that the arabinogalactan liberated from the infusion has a protectiveanti-ulcer effect.
3)-linked hars/beta2.gif" BORDER=0 ALIGN="middle">-D-Galp main chain, substituted at O-6 by(16)-linked hars/beta2.gif" BORDER=0 ALIGN="middle">-D-Galp chains, which were mainly substituted at O-3 by (15)- and (13)-linked hars/alpha.gif" BORDER=0>-L-Araf chains, andnonreducing end-units of hars/alpha.gif" BORDER=0>-L-Araf and 4-O-Me-GlcpA. This polysaccharide significantly inhibited ethanol-induced gastriclesions in rats with an ED50 of 9.3 mg/kg, suggesting that the arabinogalactan liberated from the infusion has a protectiveanti-ulcer effect.