Development of an in Silico Profiler for Mitochondrial Toxicity

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• 作者：Mark D. Nelms ; Claire L. Mellor ; Mark T. D. Cronin ; Judith C. Madden ; Steven J. Enoch
• 刊名：Chemical Research in Toxicology
• 出版年：2015
• 出版时间：October 19, 2015
• 年：2015
• 卷：28
• 期：10
• 页码：1891-1902
• 全文大小：405K
• ISSN：1520-5010

文摘

This study outlines the analysis of mitochondrial toxicity for a variety of pharmaceutical drugs extracted from Zhang et al. ((2009) Toxicol. In Vitro, 23, 134鈥?40). These chemicals were grouped into categories based upon structural similarity. Subsequently, mechanistic analysis was undertaken for each category to identify the molecular initiating event driving mitochondrial toxicity. The mechanistic information elucidated during the analysis enabled mechanism-based structural alerts to be developed and combined together to form an in silico profiler. This profiler is envisaged to be used to develop chemical categories based upon similar mechanisms as part of the adverse outcome pathway paradigm. Additionally, the profiler could be utilized in screening large data sets in order to identify chemicals with the potential to induce mitochondrial toxicity.