A series of i
midazo[1,2-
a]pyridines which directly bind to HCV Non-Structural Protein 4B (NS4B) is described. This series de
monstrates potent
in vitro inhibition of HCV replication (EC
50 < 10 nM), direct binding to purified NS4B protein (IC
50 < 20 nM), and an HCV resistance pattern associated with NS4B (H94N/R, V105L/M, F98L) that are unique a
mong reported HCV clinical assets, suggestive of the potential for additive or synergistic co
mbination with other s
mall
molecule inhibitors of HCV replication.
Keywords:
NS4B; hepatitis C virus; midazo%5C%5B1%2C2%5C-a%5C%5Dpyridines&qsSearchArea=searchText">imidazo[1,2-a]pyridines; replicon