Unexpected Preferential Dehydration of Artemisinin in Ionic Liquids

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• 作者：Marc W. Sanders ; Lawrence Wright ; Lauren Tate ; Gayle Fairless ; Lorna Crowhurst ; Neil C. Bruce ; Adam J. Walker ; Guy A. Hembury ; Seishi Shimizu
• 刊名：Journal of Physical Chemistry A
• 出版年：2009
• 出版时间：September 24, 2009
• 年：2009
• 卷：113
• 期：38
• 页码：10143-10145
• 全文大小：127K
• 年卷期：v.113,no.38(September 24, 2009)
• ISSN：1520-5215

文摘

Thermodynamic measurements (at 298 K) reveal that a crucial step in the extraction process of the key antimalarial drug artemisinin by ionic liquids (ILs), namely, precipitation through the addition of water, is driven by artemisinin dehydration due to the differences in the water’s interaction with the bulk ILs, rather than with the artemisinin itself.