Antifungal Activity against Plant Pathogens of Metabolites from the Endophytic Fungus Cladosporium cladosporioides
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- 作者：Xiaoning Wang ; Mohamed M. Radwan ; Amer H. Tar谩wneh ; Jiangtao Gao ; David E. Wedge ; Luiz H. Rosa ; Horace G. Cutler ; Stephen J. Cutler
- 刊名：Journal of Agricultural and Food Chemistry
- 出版年：2013
- 出版时间：May 15, 2013
- 年：2013
- 卷：61
- 期：19
- 页码：4551-4555
- 全文大小：286K
- 年卷期：v.61,no.19(May 15, 2013)
- ISSN：1520-5118
文摘
Bioassay-guided fractionation of Cladosporium cladosporioides (Fresen.) de Vries extracts led to the isolation of four compounds, including cladosporin, 1; isocladosporin, 2; 5鈥?hydroxyasperentin, 3; and cladosporin-8-methyl ether, 4. An additional compound, 5鈥?6-diacetylcladosporin, 5, was synthesized by acetylation of compound 3. Compounds 1鈥?b>5 were evaluated for antifungal activity against plant pathogens. Phomopsis viticola was the most sensitive fungus to the tested compounds. At 30 渭M, compound 1 exhibited 92.7, 90.1, 95.4, and 79.9% growth inhibition against Colletotrichum acutatum, Colletotrichum fragariae, Colletotrichum gloeosporioides, and P. viticola, respectively. Compound 2 showed 50.4, 60.2, and 83.0% growth inhibition at 30 渭M against Co. fragariae, Co. gloeosporioides, and P. viticola, respectively. Compounds 3 and 4 were isolated for the first time from Cl. cladosporioides. Moreover, the identification of essential structural features of the cladosporin nuclei has also been evaluated. These structures provide new templates for the potential treatment and management of plant diseases.