Heteroaromatic Moieties in the Sphingosine Backbone of 伪-Galactosylceramides for Noncovalent Interactions with CD1d
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- 作者：Yongju Kim ; Jonghoon Kim ; Keunhee Oh ; Dong-Sup Lee ; Seung Bum Park
- 刊名：ACS Medicinal Chemistry Letters
- 出版年：2012
- 出版时间：February 9, 2012
- 年：2012
- 卷：3
- 期：2
- 页码：151-154
- 全文大小：315K
- 年卷期：v.3,no.2(February 9, 2012)
- ISSN：1948-5875
文摘
A series of 伪-GalCer analogues containing heterocyclic and aromatic moieties in the sphingosine backbone were synthesized to improve the selectivity in the Th1/Th2 cytokine profile via noncovalent interaction with three aromatic residues at the binding pocket of CD1d. In vitro and in vivo biological evaluations revealed the treatment of 伪-GalCer analogue (6) induced the selective stimulation of natural killer T cells to facilitate the secretion of Th2 cytokines.