Highly Enantioselective One-Pot Synthesis of Chiral 尾-Hydroxy Sulfones via Asymmetric Transfer Hydrogenation in an Aqueous Medium
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- 作者：Dacheng Zhang ; Tanyu Cheng ; Qiankun Zhao ; Jianyou Xu ; Guohua Liu
- 刊名：Organic Letters
- 出版年：2014
- 出版时间：November 7, 2014
- 年：2014
- 卷：16
- 期：21
- 页码：5764-5767
- 全文大小：345K
- ISSN：1523-7052
文摘
A mild transformation in an aqueous medium for the one-pot synthesis of optically active 尾-hydroxy sulfones is described. The intermediates of 尾-keto sulfones obtained via a nucleophilic substitution reaction of 伪-bromoketones and sodium sulfinates in H2O/MeOH (1:3, v/v) at 50 掳C were reduced through Ru-catalyzed asymmetric transfer hydrogenation in one-pot using HCOONa as a hydrogen source providing a variety of chiral 尾-hydroxy sulfones with high yields and excellent enantioselectivities.