Novel Nanocomposite of Nano Fe3O4 and Polylactide Nanofibers for Application in Drug Uptake and Induction of Cell Death of Leukemia Cancer Cells

详细信息    查看全文

• 作者：Gang Lv ; Fang He ; Xuemei Wang ; Feng Gao ; Gen Zhang ; Tao Wang ; Hui Jiang ; Chunhui Wu ; Dadong Guo ; Xiaomao Li ; Baoan Chen ; Zhongze Gu
• 刊名：Langmuir
• 出版年：2008
• 出版时间：March 4, 2008
• 年：2008
• 卷：24
• 期：5
• 页码：2151 - 2156
• 全文大小：452K
• 年卷期：v.24,no.5(March 4, 2008)
• ISSN：1520-5827

文摘

Novel nanocomposites of polylactide (PLA) nanofibers and tetraheptylammonium-capped Fe₃O₄ magneticnanoparticles have been prepared and utilized to realize the efficient accumulation of anticancer drug daunorubicinin target cancer cells. The observations of optical microscopy and confocal fluorescence microscopy indicate that thePLA nanofibers and Fe₃O₄ nanoparticles may contribute to their beneficial effects on intracellular drug uptake ofleukemia K562 cell lines in which the efficiently enhanced accumulation of anticancer drug daunorubicin on themembrane of cancer cells could be observed. Meanwhile, the electrochemical detection and the microculture tetrazoliumstudies were also explored to probe the effect of the relevant nanomaterials on the drug uptake of cancer cells. Theresults illustrate that the nanocomposites could effectively facilitate the interaction of daunorubicin with leukemia cellsand remarkably enhance the permeation and drug uptake of anticancer agents in the cancer cells, which could readilylead to the induction of the cell death of leukemia cells. This observation suggests a new perspective for the targetedtherapeutic approaches of cancers.