文摘
The evidence is quite limited regarding the constituents of fine particulate matter (PMb>2.5b>) responsible for lung dysfunction. We designed a time-series panel study in 28 patients to examine the effects of 10 major constituents of PMb>2.5b> on lung function with repeated daily measurements from December 2012 to May 2013 in Shanghai, China. We applied a linear mixed-effect model combined with a distributed lag model to estimate the cumulative effects of PMb>2.5b> constituents on morning/evening forced expiratory volume in 1-s (FEVb>1b>) and peak expiratory flow (PEF) over a week. The cumulative decreases in morning FEVb>1b>, evening FEVb>1b>, morning PEF and evening PEF associated with an interquartile range (35.8 μg/m3) increase in PMb>2.5b> concentrations were 33.49 [95% confidence interval(CI):2.45,54.53] mL, 16.80 (95%CI:3.75,29.86) mL, 4.48 (95%CI:2.30,6.66) L/min, and 1.31 (95%CI:-0.85,3.47) L/min, respectively. These results were not substantially changed after adjusting for gases in two-pollutant models. The associations of elemental carbon (EC) and nitrates with morning/evening FEVb>1b>, and the associations of EC and sulfates with morning PEF were robust after controlling for PMb>2.5.b> This study demonstrated that short-term exposure to PMb>2.5b> was associated with reduced pulmonary function. Some constituents (EC, sulfate and nitrate) may be responsible for the detrimental effects.