Pinnarine, Another Member of the Halichlorine Family. Isolation and Preparation from Pinnaic Acid

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• 作者：Shu Xu ; Hideaki Yoshimura ; Norihito Maru ; Osamu Ohno ; Hirokazu Arimoto ; Daisuke Uemura
• 刊名：Journal of Natural Products
• 出版年：2011
• 出版时间：May 27, 2011
• 年：2011
• 卷：74
• 期：5
• 页码：1323-1326
• 全文大小：717K
• 年卷期：v.74,no.5(May 27, 2011)
• ISSN：1520-6025

文摘

Pinnarine (1), a new macrocyclic alkaloid, was isolated from the black marine sponge Halichondria okadai. The structure was elucidated on the basis of 2D NMR and comparison with the spectra of the co-isolated known halichlorine. Further confirmation of the structure and the absolute configuration was validated by a synthetic method from authentic pinnaic acid and CD analysis. The isolation of pinnarine also suggested a biogenetic pathway from pinnaic acid to halichlorine.