A Continuous Homologation of Esters: An Efficient Telescoped Reduction鈥揙lefination Sequence

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• 作者：Damien Webb ; Timothy F. Jamison
• 刊名：Organic Letters
• 出版年：2012
• 出版时间：May 18, 2012
• 年：2012
• 卷：14
• 期：10
• 页码：2465-2467
• 全文大小：216K
• 年卷期：v.14,no.10(May 18, 2012)
• ISSN：1523-7052

文摘

A continuous protocol for the two-carbon homologation of esters to 伪,尾-unsaturated esters is described. This multireactor homologation telescopes an ester reduction, phosphonate deprotonation, and Horner鈥揥adsworth鈥揈mmons olefination, thus converting a three-operation procedure into a single, uninterrupted system that eliminates the need for isolation or purification of the aldehyde intermediates. The homologated products are obtained in high yield and selectivity.