Effects of Oat 尾-Glucan and Barley 尾-Glucan on Fecal Characteristics, Intestinal Microflora, and Intestinal Bacterial Metabolites in Rats
详细信息 查看全文
- 作者：Rui-Ling Shen ; Xue-Ya Dang ; Ji-Lin Dong ; Xin-Zhong Hu
- 刊名：Journal of Agricultural and Food Chemistry
- 出版年：2012
- 出版时间：November 14, 2012
- 年：2012
- 卷：60
- 期：45
- 页码：11301-11308
- 全文大小：313K
- 年卷期：v.60,no.45(November 14, 2012)
- ISSN：1520-5118
文摘
The primary objective was to determine the beneficial effects of oat 尾-glucan (OG) and barley 尾-glucan (BG) on gut health. A total of 200 male Sprague鈥揇awley rats were divided into 5 groups of 40 rats each, control group (CON), low-dose OG-administered group (OGL), high-dose OG-administered group (OGH), low-dose BG-administered group (BGL), and high-dose BG-administered group (BGH). OGL and OGH were administered oat 尾-glucan by intragastric gavage at a dose of 0.35 g/kg of body weight (BW) and 0.70 g/kg of BW daily for 6 weeks, and BGL and BGH were administered barley 尾-glucan. The CON received normal saline. Intestinal-health-related indexes were analyzed at baseline, week 3, week 6, and week 7. Cereal 尾-glucan significantly influenced the fecal water content, pH value, ammonia levels, 尾-glucuronidase activity, azoreductase activity, and colonic short-chain fatty acid (SCFA) concentrations (p < 0.05). Moreover, the population of Lactobacillus and Bifidobacterium increased (p < 0.05), whereas the number of Enterobacteriaceae decreased (p < 0.05) in a dose-dependent manner during the period of cereal 尾-glucan administration. These results suggested that cereal 尾-glucan might exert favorable effects on improving intestinal functions and health but the gut-health-promoting effects of oat 尾-glucan were better than those of barley 尾-glucan.