One-Pot Organocatalytic Enantioselective Domino Double-Michael Reaction and Pictet-Spengler鈥揕actamization Reaction. A Facile Entry to the 鈥淚nside Yohimbane鈥?System with Five Contiguous Stereogenic Cen

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• 作者：Bor-Cherng Hong ; Wei-Kai Liao ; Nitin S. Dange ; Ju-Hsiou Liao
• 刊名：Organic Letters
• 出版年：2013
• 出版时间：February 1, 2013
• 年：2013
• 卷：15
• 期：3
• 页码：468-471
• 全文大小：310K
• 年卷期：v.15,no.3(February 1, 2013)
• ISSN：1523-7052

文摘

An expedited method was developed for the enantioselective synthesis of dodecahydrobenz[a]indolo[3,2-h]quinolizine containing five contiguous stereogenic centers with high enantioselectivities (>99% ee). The methodology comprises a domino organocatalytic double Michael reaction and Pictet-Spengler鈥搇actamization reaction. The structures and absolute configurations of the appropriate products were confirmed by X-ray analysis.