Identification of Bacteria from Two-Dimensional Resonant-Raman Spectra

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• 作者：Jacob Grun ; Charles K. Manka ; Sergei Nikitin ; Daniel Zabetakis ; Gelu Comanescu ; David Gillis ; Jeffrey Bowles
• 刊名：Analytical Chemistry
• 出版年：2007
• 出版时间：July 15, 2007
• 年：2007
• 卷：79
• 期：14
• 页码：5489 - 5493
• 全文大小：385K
• 年卷期：v.79,no.14(July 15, 2007)
• ISSN：1520-6882

文摘

We present the first measurements of two-dimensionalresonant-Raman spectra and demonstrate the applicabilityof the method to the identification of bacteria, includingdifferentiation of genetically similar species. A new devicethat sequentially illuminates bacteria with different ultraviolet wavelengths and measures a spectrum at each wasdeveloped for this purpose. We anticipate that informationwithin such two-dimensional spectra will allow identification of bacteria and chemicals in environments containingmultiple organisms and chemicals, leading, for example,to instruments that rapidly identify bacteria in hospitaland food plant settings, for screening large populations,and for biochemical-threat warning systems.