Caging Metal Ions with Visible Light-Responsive Nanopolymersomes

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• 作者：Julianne C. Griepenburg ; Nimil Sood ; Kevin B. Vargo ; Dewight Williams ; Jeff Rawson ; Michael J. Therien ; Daniel A. Hammer ; Ivan J. Dmochowski
• 刊名：Langmuir
• 出版年：2015
• 出版时间：January 20, 2015
• 年：2015
• 卷：31
• 期：2
• 页码：799-807
• 全文大小：503K
• ISSN：1520-5827

文摘

Polymersomes are bilayer vesicles that self-assemble from amphiphilic diblock copolymers, and provide an attractive system for the delivery of biological and nonbiological molecules due to their environmental compatibility, mechanical stability, synthetic tunability, large aqueous core, and hyperthick hydrophobic membrane. Herein, we report a nanoscale photoresponsive polymersome system featuring a meso-to-meso ethyne-bridged bis[(porphinato)zinc] (PZn₂) fluorophore hydrophobic membrane solute and dextran in the aqueous core. Upon 488 nm irradiation in solution or in microinjected zebrafish embryos, the polymersomes underwent deformation, as monitored by a characteristic red-shifted PZn₂ emission spectrum and confirmed by cryo-TEM. The versatility of this system was demonstrated through the encapsulation and photorelease of a fluorophore (FITC), as well as two different metal ions, Zn²⁺ and Ca²⁺.