High Relaxivity and Stability of a Hydroxyquinolinate-Based Tripodal Monoaquagadolinium Complex for Use as a Bimodal MRI/Optical Imaging Agent

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• 作者：Gaylord Tallec ; Pascal H. Fries ; Daniel Imbert ; Marinella Mazzanti
• 刊名：Inorganic Chemistry
• 出版年：2011
• 出版时间：September 5, 2011
• 年：2011
• 卷：50
• 期：17
• 页码：7943-7945
• 全文大小：676K
• 年卷期：v.50,no.17(September 5, 2011)
• ISSN：1520-510X

文摘

An octadentate ligand based on triazacyclononane and 8-hydroxyquinolinate/phenolate binding units leads to very soluble, highly stable lanthanide complexes. The monoaquagadolinium complex shows a high relaxivity as a result of the unusually long rotational correlation time, fast water exchange rate, and slow electronic relaxation. The ligand also acts as sensitizer of the near-IR luminescence emission of the Yb and Nd ions. It appears as an excellent candidate for use as a bimodal imaging agent.