Total Synthesis of Amphirionin-4

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• 作者：Michael Holmes ; Daniel Kwon ; Matthew Taron ; Robert Britton
• 刊名：Organic Letters
• 出版年：2015
• 出版时间：August 7, 2015
• 年：2015
• 卷：17
• 期：15
• 页码：3868-3871
• 全文大小：391K
• ISSN：1523-7052

文摘

The first total synthesis of amphirionin-4 has been achieved using a combination of cross-coupling strategies to access the polyene side chain and a chlorohydrin-based approach to construct the tetrahydrofuranol core. The remote C9-stereocenter was introduced through a Nozaki鈥揌iyama鈥揔ishi coupling that proceeded with remote stereoinduction.