DNA-Based Approach for Interparticle Interaction Control
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- 作者：Dmytro Nykypanchuk ; Mathew M. Maye ; Daniel van der Lelie ; Oleg Gang
- 刊名：Langmuir
- 出版年：2007
- 出版时间：May 22, 2007
- 年：2007
- 卷：23
- 期：11
- 页码：6305 - 6314
- 全文大小：295K
- 年卷期：v.23,no.11(May 22, 2007)
- ISSN：1520-5827
文摘
Micron-sized latex particles with single-stranded DNA grafted to the surface have been used as a model systemto study DNA mediated interactions. A new approach of tuning the interactions between particles is proposed, whichallows for a gradual change of the assembly rate for fixed physical conditions of a solution by combining hybridizing"linker" DNA with nonhybridizing "neutral" DNA. The effect of linker/neutral DNA ratios on particle assemblykinetics and aggregate morphology has been experimentally investigated for a range of ionic strengths. The conditionsfor controlling various assembly morphologies have been identified, and the involved attractive and repulsive interactionshave been described and explained for the proposed approach. The calculated attractive-repulsive behavior is in goodagreement with experimental results. The described approach provides general perspectives for further fine-tuningDNA-mediated assembly systems.