Nanoparticles for Imaging, Sensing, and Therapeutic Intervention

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• 作者：Lara K. Bogart ; Genevieve Pourroy ; Catherine J. Murphy ; Victor Puntes ; Teresa Pellegrino ; Daniel Rosenblum ; Dan Peer ; Rapha毛l L茅vy
• 刊名：ACS Nano
• 出版年：2014
• 出版时间：April 22, 2014
• 年：2014
• 卷：8
• 期：4
• 页码：3107-3122
• 全文大小：691K
• 年卷期：v.8,no.4(April 22, 2014)
• ISSN：1936-086X

文摘

Nanoparticles have the potential to contribute to new modalities in molecular imaging and sensing as well as in therapeutic interventions. In this Nano Focus article, we identify some of the current challenges and knowledge gaps that need to be confronted to accelerate the developments of various applications. Using specific examples, we journey from the characterization of these complex hybrid nanomaterials; continue with surface design and (bio)physicochemical properties, their fate in biological media and cells, and their potential for cancer treatment; and finally reflect on the role of animal models to predict their behavior in humans.