Xenortide Biosynthesis by Entomopathogenic Xenorhabdus nematophila

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• 作者：Daniela Reimer ; Friederike I. Nollmann ; Katharina Schultz ; Marcel Kaiser ; Helge B. Bode
• 刊名：Journal of Natural Products
• 出版年：2014
• 出版时间：August 22, 2014
• 年：2014
• 卷：77
• 期：8
• 页码：1976-1980
• 全文大小：242K
• ISSN：1520-6025

文摘

The biosynthesis gene cluster of the xenortides and a new derivative, xenortide D, which is produced in only trace amounts, was identified in Xenorhabdus nematophila. The structure of xenortide D was elucidated using a combination of labeling experiments followed by MS analysis and was confirmed by synthesis. Bioactivity tests revealed a weak activity of tryptamine-carrying xenortides against Plasmodium falciparum and Trypanosoma brucei.